UROFEB 40 – Febuxostat 40mg Tablets (10’s) | Xanthine Oxidase Inhibitor for Gout Management

Description

UROFEB 40 – Febuxostat 40mg Tablets (10’s) | Xanthine Oxidase Inhibitor for Gout Management
Targeted Uric Acid Reduction Therapy

Category: Anti-Gout Agent
Pack Size: 10 Film-Coated Tablets

Composition (Per Tablet):

• Febuxostat 40mg

Key Benefits:
✔️ Potent Uric Acid Reduction: Lowers serum urate levels by >40%*
✔️ Dual Action: Inhibits both oxidized and reduced forms of xanthine oxidase
✔️ Renal Advantage: Safe for mild-moderate kidney impairment
✔️ Flexible Dosing: Start with 40mg, adjust based on uric acid levels

Therapeutic Uses:
• Chronic hyperuricemia in gout
• Prophylaxis of gout flares
• Tumor lysis syndrome prophylaxis (off-label)
• Patients intolerant to allopurinol

Dosage & Administration:

• Initial Dose: 1 tablet (40mg) once daily

• Dose Adjustment:

  • Increase to 80mg if serum urate >6mg/dL after 2 weeks

  • Max dose: 120mg/day (severe cases)

• Take With: Water, with/without food

Safety Profile:
🚫 Contraindications:

• Asymptomatic hyperuricemia

• Concurrent theophylline therapy

• Ischemic heart disease (caution)

⚠️ Monitor:
• Serum uric acid (target <6mg/dL)
• Liver enzymes (baseline + periodic)
• Gout flares (initial therapy)

Drug Interactions:
▲ Significant:

• Azathioprine/6-MP (↑ toxicity risk)

• Warfarin (monitor INR)

• Theophylline (↑ levels)

Storage:
• Below 30°C
• Protect from moisture