Description
Megamet PG2 Tablets (10’s) | Glimepiride 2mg + Metformin 500mg + Pioglitazone 15mg | Triple Therapy for Type 2 Diabetes Management
Category: Anti-diabetic Combination Therapy
Pack Size: 10 Tablets (Blister Pack)
Composition (Per Tablet):
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Glimepiride 2mg (Sulfonylurea – Insulin Secretagogue)
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Metformin 500mg (Biguanide – Insulin Sensitizer)
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Pioglitazone 15mg (Thiazolidinedione – PPAR-γ Agonist)
Key Benefits:
✔️ Triple-Action Control: Enhances insulin secretion, reduces insulin resistance, and improves peripheral glucose uptake
✔️ Comprehensive Glycemic Management: Targets fasting, postprandial glucose, and HbA1c
✔️ Reduced Pill Burden: Three agents in one tablet for better compliance
✔️ Synergistic Effect: Addresses multiple pathophysiological defects in type 2 diabetes
Therapeutic Uses:
• Type 2 diabetes mellitus inadequately controlled on dual therapy
• Patients with significant insulin resistance
• When optimal glycemic control is not achieved with two drugs
Dosage (Adults):
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1 tablet once or twice daily with meals
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Individualize dosing based on glycemic response and tolerability
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Take With Food to minimize gastrointestinal side effects
Safety Profile:
🚫 Contraindications:
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Type 1 diabetes mellitus
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Diabetic ketoacidosis
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Severe renal/hepatic impairment
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Heart failure (NYHA Class III-IV)
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Bladder cancer or history of hematuria
⚠️ Monitor For:
• Hypoglycemia (especially during initial therapy)
• Weight gain and fluid retention
• Liver function abnormalities
• Signs of heart failure (edema, shortness of breath)
• Bladder cancer symptoms (hematuria, dysuria)
Drug Interactions:
▲ Significant Interactions:
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Strong CYP2C8 inhibitors/inducers (affect pioglitazone levels)
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Alcohol (increased hypoglycemia and lactic acidosis risk)
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Gemfibrozil (increases pioglitazone concentration)
Storage:
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Below 30°C
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Protect from moisture and light
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Keep in original packaging
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